| Customization: | Available |
|---|---|
| CAS No.: | 9067-32-7 |
| Formula: | C14h22nnao11 |
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Sodium hyaluronate is a salt form of hyaluronic acid, a naturally occurring substance in the body. It belongs to the glycosaminoglycan family of carbohydrates and comprises repeating disaccharide units of N-acetylglucosamine and glucuronic acid. It is commonly used in the medical and cosmetic industries.
The sources of sodium hyaluronate can be both animal and bacterial. In the past, it was commonly extracted from rooster combs. Still, it is more widely produced through bacterial fermentation, where bacteria are genetically modified to produce high yields of hyaluronic acid.
Sodium hyaluronate has many uses in the medical field and cosmetics. In medicine, it is used to treat joint disorders such as osteoarthritis, as well as for eye surgery and wound healing. In cosmetics, it is used as a moisturizer and skin conditioner to improve skin texture and elasticity and reduce wrinkles. It can also be found in topical skincare products such as serums, creams, and masks. Additionally, it is used in some injectable dermal fillers to enhance facial features and restore volume loss.
| Items | Specifications | Methods |
| Appearance | White or almost white powder or fibrous aggregate | Ph.Eur. |
| Identification A. Infrared absorption B. Reaction (a) of sodium |
The IR spectrum of the sample exhibits maxima at the same wavelength as that of Ph. Eur. reference spectrum of sodium hyaluronate. Positive |
Ph.Eur.(2.2.24) Ph.Eur.(2.3. 1) |
| Appearance of solution | Clear and the absorbance at 600 nm is ≤ 0.01 |
Ph.Eur.(2.2. 1) Ph.Eur.(2.2.25) |
| H | 5.4 ~ 8.2 (0.5% Solution) | Ph.Eur.(2.2.3) |
| Intrinsic viscosity | Report the test value | Ph.Eur. |
| Molecular Weight | Report the test value | Ph.Eur., JP |
| Nucleic acids | The absorbance at 260 nm is ≤ 0.05. | Ph.Eur.(2.2.25) |
| Protein | ≤ 0.05% (on the dried substance) |
Ph.Eur. |
| Chlorides | ≤ 0.1% | Ph.Eur.(2.4.4) |
| Iron | ≤ 20 ppm (on the dried substance) | Ph.Eur. (2.2.23, MethodII) |
| Loss on drying | ≤ 10.0% | Ph.Eur.(2.2.32) |
| Microbial contamination-TAMC | ≤ 100 CFU/g | Ph.Eur.(2.6.12) |
| Bacterial endotoxins | < 0.005 IU/mg | Ph.Eur. (2.6.14) |
| Assay | 95.0% ~ 105.0% (on the dried substance) |
Ph.Eur., In-house method |
| Residual solvents: Ethanol | ≤ 0.5% | In-house method |
Sodium hyaluronate has various functions, from moisturizing and lubricating tissues to reducing inflammation and promoting tissue regeneration. Its unique properties make it a valuable ingredient in many products and treatments.
Hydration: One of the main functions of sodium hyaluronate is to hydrate the skin or other tissues. Sodium hyaluronate can hold up to 1,000 times its weight in water, making it an excellent moisturizer. When applied to the skin or injected into tissues, sodium hyaluronate helps to restore moisture and improve skin or tissue hydration.
Lubrication: Sodium hyaluronate also has lubricating properties, particularly in joints. It helps to reduce friction between joint surfaces and improve joint mobility. This makes it beneficial in joint injections for conditions such as osteoarthritis.
Anti-inflammatory: Sodium hyaluronate has been found to have anti-inflammatory properties, which can help to reduce pain and swelling. It is thought to inhibit the production of pro-inflammatory cytokines and enzymes, reducing inflammation.
Tissue Regeneration: Sodium hyaluronate has been found to stimulate tissue regeneration in various tissues, including skin and bone. It can help to promote the growth of new cells and tissues, leading to faster healing and tissue repair.
Anti-aging: Sodium hyaluronate is a popular ingredient in anti-aging skincare products due to its ability to improve hydration and reduce the appearance of fine lines and wrinkles. It helps plump the skin and improve skin elasticity, leading to a more youthful appearance.
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