| Customization: | Available |
|---|---|
| CAS No.: | 64519-82-0 |
| Formula: | C24h48o22 |
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| GPs+Gpm-content | 98.0% --102.0% of which43--%-57% is gps |
| water(free and crystal) | ≤7.0% |
| D-sorbitol | ≤0.5% |
| D-mannitol | ≤0.5% |
| reducing sugars(as glucose) | ≤0.3% |
| total sugar(as glucose) | ≤0.5% |
| related products | ≤2.0% |
| ash content | ≤0.05% |
| nickel | ≤2mt/kg |
| arsenic | ≤0.2mt/kg |
| lead | ≤0.3mt/kg |
| copper | ≤0.2mt/kg |
| total heavy matal(as lead) | ≤10mt/kg |
| aerobic bacterial count | ≤500cfu/g |
| coliform bacteria | ≤3Mpn/g |
| causative organism | negative |
| yeasts and moulds | ≤10cfug/g |
| particle size | min.90%(≤180um) |
| Isomalt Basic information |
| Description Properties Preparation Uses Absorption Side Effects Precautions |
| Product Name: | Isomalt |
| Synonyms: | alpha-D-glucopyranosyl-1,6-D-sorbitolpolymerwithD-Mannitol;mixedwith1-o-alpha-d-glucopyranosyl-d-glucito;Isomaleone glycol;yimaiyatonyangsun;Mixture Of 1-(4-Fluorophenyl-3S-[3-(4-Fluorophenyl-3S-Hydroxypropyl]-4S-(4-Hydroxyphenyl-AzetidiN-2-One And 1-(4-Fluorophenyl-3R-[3-(4-Fluorophenyl-3R-Hydroxypropyl]-4R-(4-Hydroxyphenyl-Azetidin;IsomaltitolFcciv;Isomaltitol;ISOMALT USP |
| CAS: | 64519-82-0 |
| MF: | C24H48O22 |
| MW: | 688.62 |
| EINECS: | 613-617-0 |
| Product Categories: | Dextrins,Sugar & Carbohydrates;Food & Flavor Additives;Food additive and Sweetener;Halogenated Heterocycles ,Thiophenes ,Thiazolines/Thiazolidines |
| Mol File: | 64519-82-0.mol |
| Isomalt Chemical Properties |
| Boiling point | 788.5±60.0 °C(Predicted) |
| density | 1.69±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, practically insoluble in anhydrous ethanol. |
| pka | 12.89±0.70(Predicted) |
| form | neat |
| InChIKey | RWJWQKXVEITNKS-JSOWRAQNSA-N |
| CAS DataBase Reference | 64519-82-0(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-37/38-41-48 |
| Safety Statements | 22-26-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | LZ4394500 |
| HS Code | 2940006000 |
| MSDS Information |
| Isomalt Usage And Synthesis |
| Description | Isomalt is a sugar-free sweetener that is used as an alternative to sugar due to its physical properties. Sugar alcohols such as Isomalt are absorbed sparingly into the small intestines hence it has an insignificant effect on blood sugar concentration. Isomalt provides a wide range of other benefits such as low hygroscopicity, a natural taste, minimal calories per gram and it is tooth-friendly. This sweetener can be used by anyone and it can also be beneficial as it promotes gut health in people who are on low-carb diets and diabetic patients. In the European Union, Isomalt is indicated on food labels as E/E953. |
| Properties | Isomalt is a combination of 2 sugar alcohols: gluco-sorbitol (GPS) and gluco-mannitol (GPM). It is a white crystalline compound without an odour. Isomalt is 55% as sugary as sucrose and it can dissolve readily into the mouth, leaving a cooling effect. The compound has low hygroscopicity at a relative humidity (85%). Isomalt dissolves in water at 250 C/770 F, 25 g/100g of the solution; it is sparingly soluble in ethanol. The compound has a melting point of 145-1500 C/293-3020 F and it decomposes at 1600 C/3200 F or higher temperatures. One manufacturer maintains that Isomalt does not caramelize or go through the Maillard browning interaction with amino acids. |
| Preparation | The preparation process starts with sucrose. An enzyme inhibits the link between fructose and glucose in sucrose. In the fructose segment of the disaccharide, 2 hydrogen molecules are added to the oxygen molecule present. About half of the original fructose segment from the disaccharide is transformed into mannitol and approximately half of the fructose segment of the initial disaccharide is transformed into sorbitol. Therefore, Isomalt comprises 2 disaccharide alcohols: gluco-sorbitol and gluco-mannitol. The molecular modifications that take this format make Isomalt enzymatically and chemically stable than sucrose. The stability of the compound makes it ideal for incorporation into a wide range of products and consumption based on its health-related advantages. |
| Uses | Isomalt is incorporated into sugar-free products due to its tolerable aftertaste and sweet purity. The compound can be applied to a wide range of foods such as low-fat ice-cream, milk & chilled drinks, table sugar, daubing food, baking food, corn breakfast food, chewing gum, chocolate and candy. It is also used as an anti-caking, glazing and bulking agent in low-calorie toffees, fruit spreads, smoked and frozen meat and fish, infant formulas, lozenges, pan-coated tablets, mineral/multivitamin supplements and jams. Isomalt increases the transfer of flavour in certain foods. Its gradual dissolution after consumption makes candy made from this compound last for a longer time. Isomalt does not leave behind the unpleasant cooling effect associated with other polyols. These sensory properties make it ideal for addition into flavoured applications and baked products. |
| Absorption | About 10% of the ingested compound is digested to mannitol, sorbitol and glucose in the small intestines whereas the rest is conveyed into the large intestine where it undergoes fermentation in the presence of beneficial bacteria to release short-chain fatty acids (SCFAs) and gases. The SCFAs are sparingly absorbed into the large intestine and some are consumed by the bacteria. |
| Side Effects | Isomalt functions in the same way as other sparingly digestible compounds hence its fermentation in the intestines may result in flatulence, diarrhoea, abdominal pain, and bloating if the compound is ingested in bulk. However, the consistent use of Isomalt makes one tolerant of sugar alcohols, which minimizes the probability of occurrence of associated side effects. |
| Precautions | Isomalt is not recommended for use in pregnant women, children and newborns. However, if the intake of this compound is inevitable, one should consult a doctor. |
| Description | Isomalt is an equimolar mixture of oc-D-glucopyranosyl-1,6- D-sorbitol (GPS) and α-D-glucopyranosyl-l,l-D-mannitol (GPM). The production process of isomalt involves two essential steps. In the first step, the 1,2 -glycosidic linkage between the glucose and the fructose moiety of sucrose is rearranged by an immobilized enzyme system to a 1,6 -glycosidic linkage, which is more stable and characteristic for the cross linkage in the amylopectin fraction of native starch. In the second step, the rearranged sucrose molecule, i.e., isomaltulose, is hydrogenated to the corresponding sugar alcohols. Isomalt is commercially available as a dry, white crystalline powder which is about half as sweet as sucrose. In vitro studies with intestinal disaccharidases from mammals demonstrated that isomalt is cleaved much more slowly than sucrose or maltose. A slight inhibitory effect on maltose hydrolysis and on the active transport on glucose has also been observed. Ingested isomalt is partly hydrolyzed in the small intestine and slowly absorbed in the form of glucose, sorbitol, and mannitol. The intact portion of isomalt, as well as some unabsorbed sorbitol and mannitol, reaches the distal parts of the gut where these products are fermented to volatile fatty acids. |
| Chemical Properties | White or almost white powder or granules. |
| Chemical Properties | Isomalt is a more or less equimolar mixture of 1-O-a-D-glucopyranosy-D-mannitol- dihydrate and 6-O-a-D-glucopyranosyl-D-sorbitol. Different production conditions, however, allow variations in the ratio of the two products. The solubility in water is about 24.5 % (w/w) at room temperature, but varies with the composition and increases with increasing temperature. In addition to the dry isomalt, a syrup is available. Isomalt is, depending on the concentration, approximately 45-60 % as sweet as sucrose, stable under normal processing conditions of foods, and noncariogenic. In the European Union, isomalt is approved as E 953 for a large number of food applications. It is GRAS in the United States and also approved in many other countries. Owing to its low glycemic index, isomaltulose, an intermediate of the production, has found increasing interest as a food ingredient in recent years. |
| Chemical Properties | Isomalt is a sugar alcohol (polyol) that occurs as a white or almost white powder or granular or crystalline substance. It has a pleasant sugarlike taste with a mild sweetness approximately 50-60% of that of sucrose. |
| Uses | analgesic, NSAID |
| Production Methods | Isomalt is produced from food-grade sucrose in a two-stage process. Beet sugar is converted by enzymatic transglucosidation into the reducing disaccharide isomaltulose. This undergoes catalytical hydrogenation to produce isomalt. |
| Biotechnological Production | For the production of isomalt sucrose is converted to isomaltulose which is then hydrogenated to yield a mixture of the two components of isomalt. Although the production of isomalt itself from isomaltulose is a chemical hydrogenation, transformation of sucrose into isomaltulose requires enzymatic transformation. The enzyme sucrosemutase is sensitive to glutaraldehyde, therefore crosslinking is not possible. For industrial use it is, however, not necessary to isolate the enzyme, as immobilized cells of the organism can be used. Addition of sodium alginate to the cultivated cells and subsequent addition of calcium acetate immobilizes the cells. This allows for the use of the cells in a bed reactor, and also facilitates the separation of the product from the reaction mixture. The long-term stability of the immobilized organism is high and can exceed 5,000 h, even if high sucrose concentrations of 550 g/L are used. The yields are about 80-85 % with 9-11 % of trehalulose and small quantities of other saccharides as by-products. Prior to hydrogenation, free sucrose has to be removed. This is carried out by nonviable cells of Saccharomyces cerevisiae. Remaining by-products of the reaction are converted to the respective sugar alcohols. Although the hydrogenation of isomaltulose theoretically should yield an equimolar mixture of the two constituents of isomalt, the share of each component may vary between 43-57 % depending on the conditions of hydrogenation. An alternative possibility is the direct cultivation of suitable microorganisms such as P. rubrum on sucrose-containing juices obtained during the production of beet and cane sugar. It is claimed that glucose and fructose produced during the transformation are consumed by the microorganisms which results in lower amounts of by-products. |
| Pharmaceutical Applications | Isomalt is a noncariogenic excipient used in a variety of pharmaceutical preparations including tablets or capsules, coatings, sachets, and suspensions, and in effervescent tablets. It can also be used in direct compression and wet granulation. In buccal applications such as chewable tablets it is commonly used because of its negligible negative heat of solution, mild sweetness, and 'mouth feel'. It is also used widely in lozenges, sugar-free chewing gum, and hard-boiled candies, and as a sweetening agent in confectionery for diabetics. |
| Safety | Isomalt is used in oral pharmaceutical formulations, confectionery, and food products. It is generally regarded as a nontoxic, nonallergenic, and nonirritant material. Toxicological and metabolic studies on isomalt have been summarized in a WHO report prepared by the FAO/WHO Expert Committee (JECFA), resulting in an acceptable daily intake of 'not specified'. The glycosidic linkage between the mannitol or sorbitol moiety and the glucose moiety is very stable, limiting the hydrolysis and absorption of isomalt in the small intestine. There is no significant increase in the blood glucose level after oral intake, and glycemic response is very low, making isomalt suitable for diabetics. The majority of isomalt is fermented in the large intestine. In general, isomalt is tolerated very well, although excessive consumption may result in laxative effects. Isomalt is not fermented by bacteria present in the mouth; therefore no significant amount of organic acid is produced that attacks tooth enamel. |
| storage | Isomalt has very good thermal and chemical stability. When it is melted, no changes in the molecular structure are observed. It exhibits considerable resistance to acids and microbial influences. Isomalt is non-hygroscopic, and at 25°C does not significantly absorb additional water up to a relative humidity (RH) of 85%; paracetamol (acetaminophen) tablets based on isomalt were stored for 6 months at 85% RH at 20°C and retained their physical aspect. If stored under normal ambient conditions, isomalt is chemically stable for many years. When it is stored in an unopened container at 20°C and 60% RH, a re-evaluation after 3 years is recommended. |
| Regulatory Status | GRAS listed. Accepted as a food additive in Europe. |
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